The linear hypothesis had its origin in 1927, when the geneticist Dr . H . J . Muller published a paper on his work eliciting gene mutations in fruit flies by bombarding them with radiation from X-rays.
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The most important paper in this series is where Hsu obtains the first optimum property for the likelihood ratio test of the univariate linear hypothesis, in fact essentially the first nonlocal optimum property for any hypothesis specifying the value of more than one parameter.
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